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[Diagnosis of insulin resistance by indirect methods in obese school children]
Nerkis Angulo1, Sobeida Barbella de Szarvas, Yaira Mathison
1Dpto. de Morfología y Ciencias Forenses, Escuela de Ciencias Biom6dicas y Tecnológicas, Universidad de Carabobo, Venezuela. Nerkis_a@hotmail.com
Insights
Insulin resistance (IR) is common in obese children, with the QUICKI method identifying it most frequently. Acanthosis Nigricans and increased BMI/waist circumference are linked to IR in this population.
Area of Science:
- Pediatric Endocrinology
- Metabolic Health
- Obesity Research
Background:
- Obesity negatively impacts glucose tolerance and insulin action.
- Insulin resistance (IR) is a growing concern in pediatric populations.
- Early identification of IR is crucial for preventing long-term metabolic complications.
Purpose of the Study:
- To determine the prevalence of insulin resistance (IR) using indirect methods in obese, normoglycemic school children.
- To correlate IR with clinical, anthropometric, and biochemical variables.
- To compare the effectiveness of different IR assessment methods.
Main Methods:
- A descriptive-correlational study involving 72 prepubescent school children with exogenous obesity.
- Assessment of personal/family history, Acanthosis Nigricans, and nutritional/biochemical status.
- Calculation of IR using QUICKI, HOMA, and basal insulin methods.
Main Results:
- The QUICKI method identified IR in 66.7% of participants, followed by HOMA (55.6%) and basal insulin (45.9%).
- Higher body mass index and waist circumference were significantly associated with IR (p < 0.05) by HOMA and QUICKI.
- Acanthosis Nigricans showed a statistically significant relationship with IR across all assessed methods (p < 0.05).
Conclusions:
- QUICKI, HOMA, and basal insulin indexes are effective in detecting IR in obese children.
- QUICKI and HOMA methods revealed significant differences in glucose and insulin levels between children with varying insulin sensitivities.
- The findings highlight the importance of screening for IR in obese children and the utility of Acanthosis Nigricans as a clinical marker.
Unlabelled:
Obesity leads to a deterioration of glucose tolerance and the action of insulin. The purpose of this study was to determine insulin resistance (IR) by indirect methods, and its correlation with clinical, anthropometric and biochemical variables in obese normoglycemic school children. This was a descriptive-correlational study of 72 school prepubescent children, who attended the ambulatory "El Concejo" of the University of Carabobo (UC) and at the Gastroenterology and Pediatric Nutrition service of the city hospital "Enrique Tejera" (CHET), in Valencia, Venezuela, between January-April 2011.
Inclusion Criteria:
exogenous obesity. We assessed personal and family history, presence of Acanthosis Nigricans and nutritional and biochemical status. We found a higher percentage of IR, through the use of the QUICKI method (66.7%), followed by the HOMA (55.6%) and basal insulin (45.9%). The mean (chi) indexes of body mass and waist circumference were significantly greater (p < 0.05) in patients with IR, by HOMA and QUICKI techniques. The QUICKI method detected significant differences (p < 0.05) in the values of glycemia, basal insulin and postprandial insulin, among patients with diminished and normal insulin sensitivities. While HOMA, detected these differences (p < 0.05) in the values of glycemia and basal insulin. A statistically significant relationship was observed (p < 0.05), between the presence of Acanthosis Nigricans and IR, by the HOMA, QUICKI and basal insulin methods. In conclusion, the evaluated techniques, QUICKI, HOMA and basal insulin indexes, were most effective for detecting the IR.
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