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Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: May 8, 2026

High-sensitivity Detection of Micrometastases Generated by GFP Lentivirus-transduced Organoids Cultured from a Patient-derived Colon Tumor

High-sensitivity Detection of Micrometastases Generated by GFP Lentivirus-transduced Organoids Cultured from a Patient-derived Colon Tumor

Published on: June 14, 2018

[Micrometastases: strategies for detection].

Francisco Arvelo¹

¹Centro de Biociencias, Fundación IDEA. Carretera Nacional Hoyo de la Puerta, Valle de Sartanejas, Baruta, Edo. Miranda, Venezuela. franarvelo@yahoo.com

Investigacion Clinica

|August 17, 2013

Summary

This summary is machine-generated.

Detecting micrometastasis or minimal residual disease is crucial in oncology. New diagnostic methods help identify these tiny tumors to personalize cancer treatment and prevent recurrence.

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Area of Science:

Oncology
Cancer Biology
Diagnostic Pathology

Context:

Micrometastasis and minimal residual disease pose significant challenges in cancer care.
The clinical response of these microscopic tumor foci to existing treatments remains largely unknown.
Accurate detection is vital for effective cancer management.

Purpose:

To review and evaluate novel diagnostic methods for identifying micrometastasis and minimal residual disease.
To explore techniques that enable precise location and quantification of these small tumor cell populations.
To assess advancements in diagnostic tools for residual cancer detection.

Summary:

Current immunohistochemical and molecular biology techniques allow for the detection of tumor cell microfoci in various tissues.
Advanced methods like flow cytometry and sophisticated molecular assays are available for quantifying these lesions.
This review focuses on the evaluation of emerging diagnostic strategies for residual disease.

Impact:

Enabling the identification of minimal residual disease can lead to individualized cancer treatment strategies.
Improved detection methods can help prevent disease recurrence in cancer patients.
Advances in diagnostics are key to overcoming the challenges posed by micrometastasis.