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Updated: May 8, 2026
08:07
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
[Personalized medicine in transplantation therapy]
1Department of Central Laboratory/Division of Personalized Medicine, Mie University Hospital, Tsu 514-8507, Japan. nakatani@clin.medic.mie-u.ac.jp
Rinsho Byori. the Japanese Journal of Clinical Pathology
|August 17, 2013
Summary
Pharmacogenomics, using CYP3A5 genotypes and phenotypes, helps personalize tacrolimus dosing in transplantation. This approach predicts drug concentrations and optimizes immunosuppression for better patient outcomes.
Area of Science:
- Pharmacogenomics
- Clinical pharmacology
- Transplantation medicine
Context:
- Personalized medicine is advancing, with pharmacogenomics showing promise in transplantation.
- Tacrolimus, a key immunosuppressant, is metabolized by CYP3A4 and CYP3A5 enzymes.
- CYP3A5 genetic variations (SNPs) influence its expression and activity.
Purpose:
- To explore the role of CYP3A5 pharmacogenomics in predicting tacrolimus pharmacokinetics and guiding personalized immunosuppressive therapy after organ transplantation.
- To evaluate the utility of CYP3A5 genotyping and phenotyping in liver, kidney, and bone marrow transplantation settings.
Summary:
- CYP3A5 phenotypes (expressors vs. non-expressors) correlate with tacrolimus blood concentrations.
- Preoperative assessment of CYP3A5 genotypes in recipients and donors is crucial for predicting tacrolimus pharmacokinetics in liver transplantation.
- Recipient CYP3A5 genotyping and phenotyping effectively predict early post-transplant tacrolimus levels and inform initial dosing in kidney transplantation.
Impact:
- Pharmacogenomic phenotyping of CYP3A5 supports personalized medicine in transplantation therapy.
- Future development of multiplex testing could further enhance personalized medicine across various clinical applications.
- Genotyping and phenotyping of metabolic enzymes are valuable for predicting drug efficacy and toxicity in combination therapies.
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