Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without causing...
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From "trust" to "trustworthiness": Retheorizing dynamics of trust, distrust, and water security in North America.

Environment and planning. E, Nature and space·2026
Same author

Physical activity, sports participation, and sustainable development in the Ibero-American region: a pilot implementation of indicators in Chile, Costa Rica, and Ecuador.

Frontiers in sports and active living·2025
Same author

Ab Initio Study of Formation Mechanisms and Thermochemical Properties of Reactive Oxygen Species (ROS) in Photocatalytic Processes.

International journal of molecular sciences·2025
Same author

In memoriam: Nicolaos E. Madias.

Kidney international·2025
Same author

Computational Study on the Pd-Catalyzed Pathway for the Formation of (<i>R</i>)-Methyl-(2-Hydroxy-1-Phenylethyl)Carbamate.

Molecules (Basel, Switzerland)·2025
Same author

Density Functional Theory Study of Methylene Blue Demethylation as a Key Step in Degradation Mediated by Reactive Oxygen Species.

International journal of molecular sciences·2025

Related Experiment Video

Updated: May 8, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Published on: April 7, 2021

Acid-base patterns in acute severe asthma.

Guillermo A Raimondi1, Silvia Gonzalez, Jorge Zaltsman

  • 1Department of Pulmonology, Instituto de Investigaciones Neurológicas Raúl Carrea (FLENI) , Buenos Aires , Argentina .

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|August 17, 2013
PubMed
Summary
This summary is machine-generated.

This study clarifies acid-base status in acute severe asthma (ASA), finding hypocapnia or hypercapnia are predominant. Lactic acidosis affects 11% of patients, often as a mixed disorder, potentially due to ASA and medications.

More Related Videos

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
14:48

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

Related Experiment Videos

Last Updated: May 8, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Published on: April 7, 2021

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
14:48

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

Area of Science:

  • Pulmonary Medicine
  • Critical Care Medicine
  • Nephrology

Background:

  • Acid-base status in acute severe asthma (ASA) is poorly defined, with conflicting reports on metabolic acidosis prevalence.
  • Discrepancies likely stem from varied assessment methodologies, highlighting the need for a systematic clinical approach.

Purpose of the Study:

  • To systematically examine acid-base patterns in patients with acute severe asthma (ASA).
  • To correlate acid-base disorders with disease severity and treatment effects in a well-defined patient cohort.

Main Methods:

  • Analyzed acid-base status, electrolytes, lactate, and FEV1 in 314 ASA patients without comorbidities.
  • Collected data on disease natural history and treatment interventions.

Main Results:

  • Severe airway obstruction (FEV1 25.6±10.0%) and hypoxemia (PaO2 66.1±11.9 mmHg) were prevalent.
  • Respiratory alkalosis correlated with better FEV1, while respiratory acidosis and increased lactate were associated with more severe obstruction.
  • Lactic acidosis occurred in 11% of patients, independent of PaO2 and PaCO2 levels.

Conclusions:

  • Primary hypocapnia or hypercapnia are the main acid-base disturbances in ASA.
  • Lactic acidosis in ASA often presents as a mixed disorder, possibly influenced by both the condition and sympathetic effects from medications.