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High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning
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Spatial and temporal effects in protein post-translational modification distributions in the developing mouse brain.

Alistair V G Edwards1, Gregory J Edwards, Veit Schwämmle

  • 1Department of Biochemistry and Molecular Biology, University of Southern Denmark , Campusvej 55, Odense, DK 5230, Denmark.

Journal of Proteome Research
|August 17, 2013
PubMed
Summary

Scientists propose a "PTM code" where protein post-translational modifications (PTMs) work together. This study shows PTMs co-localize in the developing brain, suggesting a complex regulatory mechanism for protein function.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Proteomics

Background:

  • Protein post-translational modifications (PTMs) regulate cellular functions.
  • Recent studies suggest evolutionary trends in PTM co-occurrence.
  • A
  • PTM code
  • hypothesis proposes complex PTM patterns control protein function.

Purpose of the Study:

  • To investigate spatiotemporal co-localization of multiple PTMs.
  • To explore potential evidence for a PTM-based functional coding mechanism.
  • To analyze PTM changes during brain development.

Main Methods:

  • Mass spectrometry
  • Proteomic strategies
  • Analysis of PTM co-localization data

Main Results:

  • Demonstrated spatiotemporal co-localization of PTMs across multiple categories.
  • Observed changes in PTM co-localization during brain development.
  • Provided biological data supporting PTM co-occurrence patterns.

Conclusions:

  • The findings suggest a potential PTM-based functional coding mechanism.
  • This mechanism could represent an additional layer of regulatory control for protein function.
  • Expanding the understanding of protein PTMs in cellular signaling networks.