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Updated: May 8, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
Effort and negative affect interact to predict cardiovascular responses to stress
Clayton J Hilmert1, Ai Ni Teoh, Michael M Roy
1a Department of Psychology , North Dakota State University , Fargo , ND , USA .
Objective:
Although traditional models posit that negative emotional responses to stress increase cardiovascular reactivity (CVR), laboratory studies have generally not found a strong emotion-CVR association. In this paper, we took a multidimensional approach to examining psychological reactions to stress in three studies.
Methods:
In each study we assessed the amount of effort exerted by a participant and the negative affect (NA) felt by the participant with different self-reported measures and an effort behavioural measure.
Results:
Our findings consistently demonstrated that NA was associated with CVR when effort was relatively high, but not when effort was relatively low.
Conclusion:
This suggests that the weak NA-CVR correlations reported in past research may have been confounded by a third effort-related variable and that CVR is significantly associated with NA under certain circumstances. Furthermore, our findings suggest that by considering the multidimensional nature of psychological responses to stress, we may come to better understand the links between stress-related emotion and physiology.
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