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Twelve years of MSOME and IMSI: a review

Amanda Souza Setti1, Daniela Paes de Almeida Ferreira Braga, Assumpto Iaconelli

  • 1Sapientiae Institute - Centro de Estudos e Pesquisa em Reprodução Humana Assistida, Rua Vieira Maciel, 62, São Paulo, SP 04503-040, Brazil; Fertility - Centro de Fertilização Assistida, Av. Brigadeiro Luis Antonio, 4545, São Paulo, SP 01401-002, Brazil.

Reproductive Biomedicine Online
|August 17, 2013
PubMed

Insights

Motile sperm organelle morphology examination (MSOME) allows real-time, high-magnification sperm evaluation, leading to intracytoplasmic morphologically selected sperm injection (IMSI). This review examines the literature on the efficacy of these advanced sperm analysis techniques.

Area of Science:

  • Reproductive Biology
  • Andrology
  • Assisted Reproductive Technology

Background:

  • Motile sperm organelle morphology examination (MSOME) provides high-magnification, real-time assessment of sperm nuclear morphology.
  • MSOME has facilitated the development of intracytoplasmic morphologically selected sperm injection (IMSI).
  • Both MSOME and IMSI are advanced techniques for evaluating sperm quality in infertility investigations.

Purpose of the Study:

  • To conduct a comprehensive literature review on the efficacy of MSOME and IMSI techniques.
  • To synthesize current research findings on the application and outcomes of MSOME and IMSI.
  • To provide an overview of the scientific literature concerning these sperm selection methods.

Main Methods:

  • Systematic review of existing scientific literature.
  • Analysis of studies investigating the effectiveness of MSOME and IMSI.
  • Compilation of data from research papers on sperm morphology and assisted reproduction.

Main Results:

  • MSOME enables detailed evaluation of sperm nuclear morphology in motile sperm.
  • IMSI, utilizing MSOME, allows for the selection of sperm with optimal morphology for microinjection.
  • Numerous studies have explored the clinical efficacy and impact of these techniques on reproductive outcomes.

Conclusions:

  • MSOME and IMSI represent significant advancements in sperm analysis and selection for assisted reproduction.
  • The literature indicates a growing body of evidence supporting the utility of MSOME and IMSI in improving fertility treatments.
  • Further research continues to refine and validate the application of these high-magnification sperm assessment techniques.
Keywords:
ICSIIMSIMSOMEsperm morphology

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