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Hsp90 inhibits α-synuclein aggregation by interacting with soluble oligomers

Soumya Daturpalli1, Christopher A Waudby, Sarah Meehan

  • 1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

Journal of Molecular Biology
|August 17, 2013
PubMed
Summary

Heat shock protein 90 (Hsp90) prevents the aggregation of toxic alpha-synuclein (α-synuclein) species linked to Parkinson's disease. This interaction renders the protein oligomers harmless and non-toxic to cells.

Keywords:
AFMBFPHSQCITCPDParkinson's diseaseQCMTEMThTaggregationamyloidatomic force microscopyblue fluorescent proteincytoprotectiveheteronuclear single quantum coherenceisothermal titration calorimetryquartz crystal microscopythioflavin Tthioflavin T assaytransmission electron microscopy

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