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CRISPR/Cas9 Genome Editing

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The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...

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Related Experiment Video

Updated: May 8, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

New and TALENted genome engineering toolbox.

Jarryd M Campbell¹, Katherine A Hartjes, Timothy J Nelson

¹Center for Translational Science Activities, Mayo Clinic, Rochester, MN 55905, USA. ekker.stephen@mayo.edu

Circulation Research

|August 17, 2013

Summary

This summary is machine-generated.

Genome engineering advances are enabling personalized cardiovascular disease treatments. Gene-editing tools help analyze genetic defects and study patient-specific disease phenotypes.

Keywords:

TALENs cardiovascular disease modeling genome engineering induced pluripotent stem cells zebrafish

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Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

Area of Science:

Genetics
Cardiovascular Medicine
Biotechnology

Background:

The postgenomic era offers new tools for understanding genetic diseases.
Personalized medicine aims to tailor treatments based on individual genetic profiles.
Cardiovascular diseases remain a major global health concern with complex genetic underpinnings.

Purpose of the Study:

To review recent advancements in genome engineering technologies.
To highlight the application of these technologies in cardiovascular disease research.
To discuss the impact of genome engineering on personalized cardiovascular medicine.

Main Methods:

Review of current literature on genome engineering techniques.
Analysis of high-throughput model systems for genetic studies.
Exploration of gene-editing tools for functional genomics.

Main Results:

Genome engineering tools enable precise sequence-specific gene modification.
These tools facilitate the study of patient-specific genetic defects in cardiovascular disease models.
Efficient gene manipulation accelerates the understanding of disease phenotypes.

Conclusions:

Genome engineering is a rapidly advancing field with significant implications for personalized medicine.
Applications in cardiovascular disease are transforming therapeutic strategies.
Future research will likely leverage these tools for novel treatment development.