Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hyperthyroidism I: Introduction

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...

Hyperthyroidism II: Pathophysiology

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...

Graves Disease II: Pathophysiology

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

Graves' Disease I: Introduction

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

Hypothyroidism II: Pathophysiology

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...

Mania and Antimanic Drugs: Overview

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Testosterone Versus Clomiphene Treatment of Hypogonadism: A Retrospective Analysis in US Veterans.

Andrology·2026

Same author

Review of Genomic Drivers of Thyroid Cancer and Their Clinical Implications.

Genes·2026

Same author

Corrigendum to "False negative rate and concordance of ThyGeNEXT®+ThyraMIR® testing with post-thyroidectomy histopathology" [J. Clin. Translat. Endocrinol. 40 (2025) 100396].

Journal of clinical & translational endocrinology·2025

Same author

False negative rate and concordance of ThyGeNEXT®+ThyraMIR® testing with post-thyroidectomy histopathology.

Journal of clinical & translational endocrinology·2025

Same author

What is hypercalcemia? The importance of fasting samples.

Cardiorenal medicine·2014

Same author

Diabetic kidney disease and the cardiorenal syndrome: old disease, new perspectives.

Endocrinology and metabolism clinics of North America·2013

Search research articles

Related Experiment Videos

Lithium-associated hyperthyroidism.

Fadi F Siyam¹, Sanaa Deshmukh, Mariana Garcia-Touza

¹Division of Endocrinology, Diabetes, and Metabolism. siyamf@health.missouri.edu.

Hospital Practice (1995)

|August 17, 2013

Summary

This summary is machine-generated.

Lithium can cause rare hyperthyroidism in bipolar disorder patients, sometimes mistaken for mania. Discontinuing lithium may resolve this thyroid condition.

Related Experiment Videos

Area of Science:

Endocrinology
Psychiatry

Background:

Lithium is a common treatment for bipolar disorder.
Known complications include goiters and hypothyroidism.
Lithium-induced hyperthyroidism is a rare but significant adverse effect.

Observation:

Hyperthyroidism can be misdiagnosed as a manic episode.
Serial thyroid function tests are crucial for monitoring patients on lithium.
This case highlights a patient experiencing lithium-associated hyperthyroidism.

Findings:

The patient's lithium-associated hyperthyroidism resolved after medication discontinuation.
Lithium-induced hyperthyroidism is often medically manageable without stopping lithium.
Discontinuation of lithium may be necessary in some cases.

Implications:

Early detection and monitoring of thyroid function are vital for patients on lithium.
Understanding lithium's potential endocrine effects improves patient management.
This case underscores the importance of considering medication side effects in psychiatric symptom presentation.