Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stereotactic Body Radiotherapy for Spinal Metastases: What are the Risks and How Do We Minimize Them?

Spine·2016
Same author

Reported Outcome Measures in Degenerative Cervical Myelopathy: A Systematic Review.

PloS one·2016
Same author

Clinical and pathological outcomes after resection of intramedullary spinal cord tumors: a single-institution case series.

Neurosurgical focus·2016
Same author

A Systematic Review of Clinical Outcomes and Prognostic Factors for Patients Undergoing Surgery for Spinal Metastases Secondary to Breast Cancer.

Global spine journal·2016
Same author

Key Preoperative Clinical Factors Predicting Outcome in Surgically Treated Patients with Metastatic Epidural Spinal Cord Compression: Results from a Survey of 438 AOSpine International Members.

World neurosurgery·2016
Same author

Impact of Depression and Bipolar Disorders on Functional and Quality of Life Outcomes in Patients Undergoing Surgery for Degenerative Cervical Myelopathy: Analysis of a Combined Prospective Dataset.

Spine·2016
Same journal

Functional Outcomes and Complications Following Very Delayed Cranioplasty: Clinical Challenges and Surgical Considerations.

World neurosurgery·2026
Same journal

Intraventricular Nicardipine for Cerebral Vasospasm in Children: A Case Series.

World neurosurgery·2026
Same journal

Application of the Ridge Board Technique in Endoscopic Treatment of Cervical Stenosis: Surgical Technique and Preliminary Results.

World neurosurgery·2026
Same journal

Global Trends and Evolving Frontiers in Intranasal Delivery for CNS Diseases (2000-2025): A Bibliometric Analysis and Systematic Review.

World neurosurgery·2026
Same journal

MAN IS A FOOL….

World neurosurgery·2026
Same journal

One-Year Clinical and Imaging Outcomes After Dedicated Sirolimus-Eluting Stenting for Symptomatic Vertebral Artery Origin Stenosis: A Real-World Cohort Study.

World neurosurgery·2026
See all related articles

Related Experiment Video

Updated: May 8, 2026

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells
13:58

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells

Published on: July 29, 2015

Adult-derived pluripotent stem cells.

Stuart D Faulkner1, Reaz Vawda1, Michael G Fehlings2

  • 1Division of Genetics and Development, Toronto Western Research Institute, Toronto, Ontario, Canada.

World Neurosurgery
|August 17, 2013
PubMed
Summary
This summary is machine-generated.

Adult-derived induced pluripotent stem cells show promise for spinal cord injury (SCI) repair. Further validation in SCI models and clinical trials are needed for this ethical stem cell therapy.

Keywords:
Adult-derived neural stem cellsCell transplantationClinical trialInduced pluripotent stem cellsSpinal cord injury

More Related Videos

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method
10:52

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

Published on: January 19, 2020

Related Experiment Videos

Last Updated: May 8, 2026

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells
13:58

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells

Published on: July 29, 2015

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method
10:52

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

Published on: January 19, 2020

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Spinal cord injury (SCI) affects millions globally, incurring substantial costs and causing significant long-term neurological deficits.
  • Current treatments offer limited functional recovery for SCI patients.
  • Cellular transplantation is a promising therapeutic strategy for promoting neural repair and regeneration in SCI.

Purpose of the Study:

  • To explore the potential of adult-derived induced pluripotent stem cells (iPSCs) as an ethical and effective cell therapy for spinal cord injury.
  • To evaluate the feasibility of using iPSC-derived neural stem and progenitor cells for promoting central nervous system repair.

Main Methods:

  • Review of advancements in stem cell generation and transfection techniques.
  • Analysis of experimental outcomes in SCI models utilizing adult-derived iPSCs.
  • Assessment of the potential for iPSC-derived neural stem and progenitor cells in SCI treatment.

Main Results:

  • Adult-derived iPSCs overcome ethical challenges associated with embryonic stem cells.
  • Improved generation and transfection techniques facilitate the production of neural lineages from iPSCs.
  • Positive experimental results in SCI models indicate the therapeutic potential of iPSC-derived cells.

Conclusions:

  • Adult-derived iPSCs represent a viable alternative to embryonic stem cells for clinical applications in SCI.
  • Further validation of iPSC-derived neural stem and progenitor cell efficacy in SCI models is crucial.
  • Rigorous early-stage clinical trials are necessary to translate this promising therapy from bench to bedside.