A suspension-cell biosensor for real-time determination of binding kinetics of protein-carbohydrate interactions on cancer cell surfaces
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Published on: April 17, 2017
Xueming Li1, Yuxin Pei, Ruina Zhang
1State Key Laboratory of Crop Stress Biology in Arid Areas and College of Science, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China. peizc@nwafu.edu.cn peiyx@nwafu.edu.cn.
Abstract:
A novel lectin-based suspension-cell biosensor for label-free determination of binding kinetics of protein-carbohydrate interactions on cancer cell surfaces using QCM is described. This cell-biosensor facilitates evaluation of glycosylation in real time on suspension cancer cell surfaces, where binding events take place, more closely mimicking a native environment compared with traditional biosensors.
