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Updated: May 8, 2026
09:31
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
Amyloid-related imaging abnormalities in AβPP duplication carriers.
Ludivine Chamard1, David Wallon, Alexa Pijoff
1Department of Neurology, Memory Resources and Research Center (CMRR), Besançon University Hospital, Besancon, France.
Journal of Alzheimer'S Disease : JAD
|August 17, 2013
Summary
Cerebral amyloid angiopathy related-inflammation (CAA-ri) involves immune responses to amyloid-β. This case study shows ARIA-E and ARIA-H in an APOE 3/3 individual with AβPP duplication, suggesting spontaneous CAA-ri resolution without genetic risk factors.
Area of Science:
- Neurology
- Immunology
- Genetics
Background:
- Cerebral amyloid angiopathy related-inflammation (CAA-ri) is an immune response to vascular amyloid-beta (Aβ) deposits.
- Amyloid-related imaging abnormalities (ARIA) are observed in anti-amyloid therapies and linked to the APOE 4/4 genotype.
Observation:
- A case of an individual with AβPP duplication and APOE 3/3 genotype is presented.
- The individual experienced ARIA-E (ARIA with effusion) followed by ARIA-H (ARIA with hemosiderin deposits).
- These events occurred spontaneously, without any anti-amyloid treatment.
Findings:
- The presentation suggests a possible spontaneously resolving CAA-ri, though not neuropathologically confirmed.
- This case indicates potential shared mechanisms between ARIA and CAA-ri.
- The occurrence in an individual without the APOE 4/4 risk factor prompts further investigation into ARIA mechanisms.
Implications:
- High vascular amyloid burden from AβPP duplication may enhance amyloid epitope presentation, potentially triggering inflammation.
- This case highlights the complexity of ARIA and CAA-ri, suggesting that APOE genotype may not be the sole determinant.
- Further research is needed to understand the spontaneous resolution of CAA-ri and its underlying mechanisms, especially in the absence of typical risk factors.
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