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Updated: May 8, 2026

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
Published on: March 22, 2016
Hippocampal neurogenesis in Alzheimer's disease: is there a role for dietary modulation?
Aleksandra Maruszak1, Adam Pilarski, Tytus Murphy
1Department of Neuroscience, Institute of Psychiatry, King's College London, London, United Kingdom.
Abstract:
Alterations in hippocampal neurogenesis have been recognized as an integral part of Alzheimer's disease. Adult hippocampal neurogenesis is regulated by intrinsic and extrinsic factors; one of them is diet. This review provides an assessment of the current state of the field in hippocampal neurogenesis studies in Alzheimer's disease and focuses on the role of diet. The review highlights some of the key dietary compounds and interventions such as calorie restriction, fat, polyphenols, zinc, folate, alcohol and thiamine, and emphasizes the pathways that they modify.
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