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Updated: May 8, 2026

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Lab-on-chip device for single cell trapping and analysis.

Pratikkumar Shah¹, Xuena Zhu, Chunying Chen

¹Biomedical Engineering Department, Florida International University, Miami, FL, USA.

Biomedical Microdevices

|August 17, 2013

Summary

This summary is machine-generated.

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This study introduces a novel lab-on-chip device for high-throughput single-cell nanotoxicity analysis. This technology enables precise manipulation and analysis of individual cells, overcoming limitations of traditional population-based assays.

Area of Science:

Biomedical Engineering
Nanotechnology
Cell Biology

Background:

Traditional cell assays provide population-level data, obscuring crucial single-cell variations.
Individual cell heterogeneity significantly impacts cellular function and disease processes.
Advanced single-cell analysis methods are essential for uncovering biological principles and improving disease treatment.

Purpose of the Study:

To develop a high-throughput lab-on-chip device for single-cell nanotoxicity analysis.
To enable precise manipulation and real-time monitoring of individual cells.
To establish a novel platform for nanotoxicity assessment and drug testing at the single-cell level.

Main Methods:

Fabrication of a lab-on-chip device with independently addressable active microwell electrodes.

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Published on: September 27, 2019

Related Experiment Videos

Last Updated: May 8, 2026

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Cell Capture Using a Microfluidic Device

Cell Capture Using a Microfluidic Device

Published on: October 1, 2007

Establishing Single-Cell Based Co-Cultures in a Deterministic Manner with a Microfluidic Chip

Establishing Single-Cell Based Co-Cultures in a Deterministic Manner with a Microfluidic Chip

Published on: September 27, 2019

Utilizing positive dielectrophoresis for efficient and controlled single-cell capture in microwells.

Monitoring impedance properties to confirm cell capture, viability, and health within microwells.

Main Results:

Successful implementation of dielectrophoresis for high-throughput single-cell isolation.
Demonstrated ability to monitor cellular responses at the individual cell level.
Validated a novel model for single-cell nanotoxicity and drug testing assays.

Conclusions:

The developed lab-on-chip device offers a powerful tool for high-throughput single-cell analysis.
This approach overcomes the limitations of traditional assays by revealing single-cell heterogeneity.
The platform holds significant potential for advancing nanotoxicity studies and personalized drug testing.