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Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...

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Dermatologie (Heidelberg, Germany)·2026
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Validation of the French translation of the Prurigo Control Test (PCT) questionnaire.

Annales de dermatologie et de venereologie·2026
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The Prurigo Control Test reflects the severity of itch and skin lesions in patients with chronic prurigo: Data from a real-world study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
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A cross-sectional study on gender differences in body dysmorphic concerns in patients with skin conditions in relation to sociodemographic, clinical and psychological variables.

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[Patient survey on the use of video consultation in the outpatient treatment of chronic pruritus].

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Acceptability and perceived benefits of validated pruritus assessment instruments in the dermatological office and clinic: The perspectives of patients and physicians.

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Related Experiment Video

Updated: May 8, 2026

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay
05:52

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay

Published on: May 12, 2023

[Primary and secondary neutropenia].

C Zeidler1

  • 1Abteilung für Molekulare Hämatopoese, Kinderklinik, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland. Zeidler.Cornelia@mh-hannover.de

Zeitschrift Fur Rheumatologie
|August 17, 2013
PubMed
Summary

Severe chronic neutropenia (SCN) is a group of disorders with low neutrophil counts, increasing infection risk. Genetic insights and growth factor treatments significantly improve patient prognosis and quality of life.

Area of Science:

  • Hematology
  • Genetics
  • Immunology

Context:

  • Severe chronic neutropenia (SCN) is defined by absolute neutrophil counts (ANC) below 0.5 × 10^9/L.
  • SCN presents a high risk of severe bacterial infections.
  • Distinguishing primary from secondary neutropenia and identifying gene mutations are crucial for prognosis.

Purpose:

  • To highlight the significance of understanding genetic mutations in neutropenia.
  • To emphasize the diagnostic differences between childhood and adulthood neutropenia.
  • To underscore the value of congenital neutropenias for hematopoiesis research.

Summary:

  • Over 10 gene mutations linked to SCN have been identified, often associated with increased leukemia risk.
  • Primary autoimmune neutropenia is common in children, while secondary neutropenia is more prevalent in adults.

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The Isolation and Characterization of Low- and Normal- Density Neutrophils from Whole Blood
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The Isolation and Characterization of Low- and Normal- Density Neutrophils from Whole Blood

Published on: February 7, 2025

Related Experiment Videos

Last Updated: May 8, 2026

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay
05:52

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay

Published on: May 12, 2023

The Isolation and Characterization of Low- and Normal- Density Neutrophils from Whole Blood
07:17

The Isolation and Characterization of Low- and Normal- Density Neutrophils from Whole Blood

Published on: February 7, 2025

  • Congenital neutropenias, though rare, offer critical insights into normal and pathological hematopoiesis.

    • Impact:

    • Hematopoietic growth factor treatment has dramatically improved SCN patient outcomes.
    • Effective treatment prevents bacterial infections, enabling normal daily life participation.
    • Research into SCN genetics advances the understanding of hematopoiesis and leukemia development.