Thiolated 2-methacryloyloxyethyl phosphorylcholine for an antifouling biosensor platform

Area of Science:

• Biomaterials Science
• Surface Chemistry
• Nanotechnology

Background:

• Self-assembled monolayers (SAMs) are crucial for surface functionalization.
• Protein and cell adhesion can interfere with biosensing performance.
• Developing biocompatible and repellent surfaces is essential for advanced diagnostics.

Purpose of the Study:

• To synthesize a novel building block for protein- and cell-repellant SAMs.
• To functionalize noble metal electrodes for improved biosensing.
• To minimize noise signals in biosensing applications.

Main Methods:

• Synthesis of a thiolated 2-methacryloyloxyethyl phosphorylcholine (MPC) derivative.
• Utilizing Michael-type addition for molecule synthesis.
• Formation of SAMs on noble metal electrodes.

Main Results:

• Successfully developed a new thiolated MPC building block.
• Demonstrated the ability of the thiolated MPC to form SAMs.
• Indicated potential for noise signal reduction in biosensing.

Conclusions:

• The novel thiolated MPC is a promising building block for repellant SAMs.
• This functionalization strategy can enhance biosensor performance.
• Further research can explore applications in sensitive bioelectronic devices.