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Corrigendum to "The apolipoprotein gene: a modulating role on brain volume and cognitive function in carriers of the fragile X premutation" [Neurobiology of Disease 2026 Feb 2; 220:107292, Page 1-13].

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Related Experiment Video

Updated: May 8, 2026

Dissecting Cell-Autonomous Function of Fragile X Mental Retardation Protein in an Auditory Circuit by In Ovo Electroporation

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Published on: July 6, 2022

Fragile X syndrome: an aging perspective.

Andrea Schneider¹, Andrew Ligsay, Randi J Hagerman

¹MIND Institute, University of California at Davis Medical Center, Sacramento, California, USA. andrea.schneider@ucdmc.ucdavis.edu

Developmental Disabilities Research Reviews

|August 17, 2013

Summary

Research on aging in fragile X spectrum disorders is limited. This review examines cellular and clinical aging in fragile X syndrome and FMR1 premutation, highlighting sparse long-term outcome data.

Keywords:

FMRP aging fragile X syndrome neurodegeneration

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Area of Science:

Neuroscience
Genetics
Gerontology

Background:

Extensive research exists on cognitive and behavioral aspects linked to FMR1 gene variations.
Limited studies focus on the long-term outcomes and aging processes in individuals with fragile X spectrum disorders.

Purpose of the Study:

To review current aging research in fragile X syndrome and FMR1 premutation.
To summarize cellular and clinical manifestations of aging in these conditions.

Main Methods:

Literature review of aging research.
Synthesis of findings on cellular and clinical aging markers.

Main Results:

Aging research in fragile X spectrum disorders is sparse.
Identified cellular and clinical manifestations of aging in fragile X syndrome and FMR1 premutation.

Conclusions:

Further research is needed on the long-term aging trajectory in fragile X spectrum disorders.
Understanding aging is crucial for managing fragile X syndrome and FMR1 premutation.