Related Experiment Video

Updated: May 8, 2026

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
04:18

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

Preterm birth and neonatal mortality in a rural Bangladeshi cohort: implications for health programs

A H Baqui1, H E Rosen, A C C Lee

  • 11] Department of International Health, International Center for Maternal and Newborn Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA [2] Center for Child and Adolescent Health, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Mohakhali, Dhaka, Bangladesh.

Journal of Perinatology : Official Journal of the California Perinatal Association
|August 17, 2013
PubMed

Insights

Preterm birth impacts nearly 20% of newborns, contributing significantly to neonatal mortality. Management strategies focusing on moderate and late preterm infants are crucial for reducing deaths in community settings.

Area of Science:

  • Neonatal Health
  • Public Health
  • Maternal-Fetal Medicine

Background:

  • Prematurity is a leading cause of neonatal mortality globally.
  • Understanding gestational age-specific risks is vital for targeted interventions.
  • Community-based data collection offers insights into real-world birth outcomes.

Purpose of the Study:

  • To quantify the burden of preterm birth.
  • To determine gestational age-specific neonatal mortality rates.
  • To inform public health programs with actionable recommendations.

Main Methods:

  • Prospective community-based study involving 10,585 mother-newborn pairs.
  • Data collection by trained community health workers on pregnancy, childbirth, and newborn outcomes.
  • Analysis of gestational age and neonatal mortality rates.

Main Results:

  • 19.4% of infants were born preterm, with late preterm (34-36 weeks) being the largest subgroup.
  • Preterm infants accounted for 46% of all neonatal deaths.
  • Gestational age-specific analyses revealed significant mortality contributions from very, moderate, and late preterm births.

Conclusions:

  • Moderate and late preterm infants represent a critical target group for intervention.
  • Home-based or first-level facility management may be effective in settings with limited referral capacity.
  • Public health strategies should consider tailored approaches for different preterm subgroups.
Abstract

More Related Videos

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

Related Concept Videos

Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Methods Of Healthcare Delivery System01:26

Methods Of Healthcare Delivery System

At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is limited...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Regression Toward the Mean01:52

Regression Toward the Mean

Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when researchers try to extrapolate results...