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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...

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Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
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Changes in circulating microRNAs levels with exercise modality.

Sébastien Banzet1, Mounir Chennaoui, Olivier Girard

  • 1Institut de Recherche Biomédicale des Armées, Armed Forces Biomedical Research Institute, Brétigny sur Orge, France;

Journal of Applied Physiology (Bethesda, Md. : 1985)
|August 17, 2013
PubMed
Summary
This summary is machine-generated.

Exercise mode influences circulating microRNAs (miRNAs). Muscle-specific miRNAs indicate muscle damage after eccentric exercise, while muscle-related miRNAs may signal adaptations to high-intensity concentric exercise.

Keywords:
biomarkerscardiac miRNAsmuscle injurymuscle miRNAs

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Area of Science:

  • Exercise Physiology
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Circulating microRNAs (miRNAs) are potential biomarkers for muscle injury and physiological adaptation.
  • Understanding how different exercise modes affect miRNA profiles is crucial for interpreting their roles.

Purpose of the Study:

  • To investigate the impact of eccentric (downhill) versus concentric (uphill) exercise on plasma muscle-specific and muscle-related miRNAs.
  • To determine if these miRNAs can serve as biomarkers for muscle damage or signaling molecules.

Main Methods:

  • Nine healthy subjects performed 30-minute downhill and uphill walking exercises on separate days.
  • Plasma miRNA levels were measured before, immediately after, and up to 72 hours post-exercise.
  • Serum creatine kinase and myoglobin were also assessed to evaluate muscle damage.

Main Results:

  • Eccentric exercise significantly increased plasma levels of hsa-mir-1, 133a, 133b, and 208b during early recovery (2-6 hours).
  • Concentric exercise led to transient increases in hsa-mir-181b and 214 immediately post-exercise.
  • Muscle-specific miRNAs (hsa-mir-1, 133a, 133b, 208b) responded to eccentric exercise, while muscle-related miRNAs (hsa-mir-181b, 214) responded to concentric exercise.

Conclusions:

  • Circulating miRNA changes are exercise mode-dependent.
  • Muscle-specific miRNAs show potential as biomarkers for eccentric exercise-induced muscle damage.
  • Muscle-related miRNAs may act as markers or mediators of physiological adaptations to high-intensity exercise.