Related Experiment Video
Updated: May 8, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Lymphocyte-suppressing action of simvastatin in patients with isolated hypertriglyceridemia
Robert Krysiak1, Bogusław Okopień
1Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland. r.krysiak@interia.pl
Background:
No previous study examined whether statins affect lymphocyte cytokine release in patients with isolated hypertriglyceridemia.
Methods:
The study included 46 patients with elevated triglyceride levels and peripheral artery stenosis, randomly assigned to receive simvastatin or placebo. Plasma lipids, glucose homeostasis markers, plasma C-reactive protein and lymphocyte cytokine release were measured at baseline and at the end of the treatment.
Results:
Ninety-day simvastatin treatment reduced lymphocyte release of TNF-α, interleukin-2 and interferon-γ, which was accompanied by a decrease in plasma C-reactive protein.
Conclusion:
The obtained results suggest that statins produce lymphocyte-suppressing and systemic anti-inflammatory effects in patients with isolated hypertriglyceridemia.
Related Concept Videos
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Atherosclerosis III: Management
Cholesterol: Significance and Regulation
Considering cholesterol and...
Lipid Absorption
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
Lipid Digestion
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are typically...