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[Not Available].

Annie Charbonneau1

  • 1, B. Pharm, M. Sc., est pharmacienne ayant pour secteurs de pratique la médecine interne, la gériatrie ainsi que le Centre d'Information pharmacothérapeutique, Centre universitaire de santé McGill (CUSM), Montréal, Québec.

The Canadian Journal of Hospital Pharmacy
|August 17, 2013
PubMed
Summary
This summary is machine-generated.

Methylene blue combined with serotonin reuptake inhibitors (SRIs) can cause dangerous serotonergic toxicity, even at low doses. Healthcare providers should exercise caution when prescribing these combinations to avoid adverse events.

Keywords:
methylene bluemethylthioniniummonoamine oxidase inhibitorsserotonin reuptake inhibitorsserotonin syndrome

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Area of Science:

  • Pharmacology
  • Clinical Toxicology
  • Drug Interactions

Context:

  • Methylene blue is a widely used medical agent.
  • Recent evidence suggests a potential for dangerous interactions with serotonin reuptake inhibitors (SRIs).
  • Serotonergic toxicity is a serious concern in polypharmacy.

Purpose:

  • To systematically review and describe the risk of serotonergic toxicity.
  • To investigate the interaction between methylene blue and SRIs.
  • To synthesize available evidence on this drug interaction.

Summary:

  • A systematic literature search identified 18 case reports and 2 case series concerning methylene blue and SRI interactions.
  • Case data indicate that serotonergic toxicity can occur at methylene blue doses as low as 0.7 mg/kg when co-administered with SRIs.
  • Methylene blue exhibits monoamine oxidase A inhibitory properties, contributing to the risk of serotonin syndrome.

Impact:

  • Highlights the potential for serious adverse events from combining methylene blue with SRIs.
  • Underscores the need for clinical vigilance and precautions when using these medications together.
  • Informs prescribing practices to mitigate the risk of drug-induced serotonergic toxicity.