Histomorphometric interpretation of bone biopsies for the evaluation of osteoporosis treatment

Bone histomorphometry is a valuable tool in the evaluation of bone safety and the mechanism of action of drugs used in the treatment of osteoporosis. Recent studies in patients treated with anti-resorptive agents have highlighted technical issues, in particular, related to the calculation of dynamic indices of bone turnover using fluorochrome labelling. This review addresses the need for standardised approaches for overcoming these problems in order to enable valid comparison of the effects of different interventions on bone remodelling.