Related Experiment Video
Updated: May 8, 2026
Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
Published on: December 10, 2010
Enhanced activity of demineralised bone matrix augmented with xenogeneic bone morphogenetic protein complex in rats
G U Mohangi1, B Rothman, A W van Zyl
1Department of Oral Medicine and Periodontology, School of Oral Health Sciences, University of the Witwatersrand, South Africa. mohangi@iafrica.com
Introduction:
Demineralised bone matrix (DBM) is an allograft material widely used as a bone filler and bone graft substitute. DBM contains bone morphogenetic proteins (BMPs), which induce and regulate bone formation during embryogenesis and in postnatal life.
Aims And Objectives:
To investigate the osteoinductivity of DBM augmented with xenogeneic BMP-complex at different doses.
Materials And Methods:
Rat DBM was augmented with BMP-complex purified from porcine diaphyseal bone.
Results:
Dorsal subcutaneous implantation of 25 mg rat allogeneic DBM augmented with 0, 3, 6 and 12 mg BMP-complex per gram of DBM resulted in dose dependant up-regulation of bone formation on day 21, as scored histologically and biochemically.
Conclusions:
Allogeneic DBM can be augmented with xenogeneically sourced BMP-complex to improve DBM performance in vivo. This work demonstrates the potential of BMP-complex augmented DBM to induce new bone formation with improved parameters of bone formation.
More Related Videos
08:41Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
04:32Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions
Published on: December 30, 2025