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[Defects of neutrophil function in chronic gastroduodenitis in children]

E V Agafonova, T G Malanicheva, S N Denisova

    Eksperimental'Naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology
    |August 20, 2013
    PubMed

    Insights

    Chronic gastroduodenitis in children involves neutrophils. Fungal infections like Candida albicans alongside Helicobacter pylori significantly impair neutrophil function, indicating a need for immunocorrection in treatment.

    Area of Science:

    • Pediatric Gastroenterology
    • Immunology
    • Microbiology

    Background:

    • Chronic gastroduodenitis (CGD) is a prevalent gastrointestinal disease in children.
    • Helicobacter pylori (HP) is a primary cause, but fungal flora, particularly Candida albicans, is increasingly implicated.
    • Understanding neutrophil function is crucial for managing pediatric CGD.

    Purpose of the Study:

    • To evaluate the functional activity of neutrophils in children with CGD.
    • To differentiate neutrophil responses to HP alone versus HP with Candida albicans co-infection.
    • To identify specific immune phenotype alterations in pediatric CGD.

    Main Methods:

    • Flow cytofluorimetry was used to study neutrophil phagocytic activity and immune phenotype.
    • 110 children aged 7-17 with CGD were analyzed.
    • Participants had CGD associated with HP, or HP and Candida albicans co-infection.

    Main Results:

    • Distinct differences in neutrophil phagocytic activity were observed between bacterial (HP) and fungal (Candida albicans) co-infections.
    • Neutrophil immune phenotype transformation correlated with depressed phagocytic and microbicidal functions.
    • Co-infection with HP and Candida albicans showed more pronounced functional impairment.
    • Candida albicans mannan protein antigen altered neutrophil surface receptors, affecting adhesion and cytolysis.

    Conclusions:

    • Pediatric CGD involves significant neutrophil phenotype transformation, varying with bacterial and fungal co-infections.
    • The findings highlight the impact of Candida albicans on neutrophil immunity in pediatric CGD.
    • Therapeutic strategies for CGD co-infected with Candida albicans should incorporate immunocorrection.

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