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Related Concept Videos

Proteins: Dietary Sources and Requirements01:28

Proteins: Dietary Sources and Requirements

Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

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Carbohydrates: Dietary Sources and Requirements01:15

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Measurement of Bioavailability: Pharmacodynamic Methods01:20

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EURRECA-Estimating folate requirements for deriving dietary reference values.

Leane Hoey1, Helene McNulty, Maresa E Duffy

  • 1Northern Ireland Centre for Food and Health (NICHE), School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, United Kingdom. l.hoey@ulster.ac.uk

Critical Reviews in Food Science and Nutrition
|August 20, 2013
PubMed
Summary

Setting dietary reference values for folate requires considering bioavailability differences between natural folate and synthetic folic acid. This review examines evidence for establishing accurate folate intake recommendations.

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Area of Science:

  • Nutritional Science
  • Public Health Nutrition

Background:

  • Dietary reference values for folate are typically based on intake levels ensuring adequate red cell and serum folate status.
  • A key challenge is accounting for varying bioavailability between natural folates and synthetic folic acid, a factor often overlooked in European countries.

Purpose of the Study:

  • To review evidence on folate intake, status, and health outcomes across the lifecycle.
  • To identify challenges and considerations for setting dietary reference values for folate, particularly regarding bioavailability.

Main Methods:

  • Conducted systematic reviews focusing on studies with robust measures of folate intake and status.
  • Examined relationships between folate intake, status, and health outcomes.

Main Results:

  • Identified significant differences in bioavailability between natural folates and folic acid.
  • Highlighted the need to incorporate bioavailability into dietary reference value calculations.

Conclusions:

  • Accurate dietary reference values for folate must consider the differential bioavailability of various folate forms.
  • Further research and consensus are needed, especially in Europe, to integrate bioavailability data into folate recommendations.