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Related Experiment Video

Updated: May 8, 2026

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
07:02

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Published on: February 11, 2019

The effect of mydriatic solutions on cognitive function.

Inci Irak Dersu1, Horace T Spencer, Paula A Grigorian

  • 1Department of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences , Little Rock, Arkansas , USA .

Seminars in Ophthalmology
|August 20, 2013
PubMed
Summary

Mydriatic eye drops did not impact cognitive function scores in a study. However, pupil dilation increased test completion time for glaucoma patients, suggesting a need for more physician explanation time for this group.

Keywords:
CognitionMocA testglaucoma/suspectmydriatic solutionsside effects

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Cognitive Science

Background:

  • Ophthalmic solutions for mydriasis can cause systemic side effects.
  • Previous research has not investigated the impact of mydriatic drops on cognitive function.

Purpose of the Study:

  • To determine if mydriatic eye drops affect cognitive functions such as memory, concentration, and orientation.

Main Methods:

  • Participants were randomized into two groups: one completing the Montreal Cognitive Assessment (MoCA) with undilated pupils and the other with dilated pupils.
  • Pupil dilation was achieved using tropicamide 0.5% and phenylephrine 2.5%.
  • The MoCA test assesses cognitive function, with scores ranging from 0-30, and a score of 26 or higher indicating normal function.

Main Results:

  • No statistically significant difference was found in MoCA scores between the dilated and undilated groups (p=0.65).
  • MoCA scores correlated significantly with education, age, and race.
  • Glaucoma patients with dilated pupils took longer to complete the MoCA test compared to non-glaucoma patients with dilated pupils (10.8 vs 8.5 minutes, p=0.02).

Conclusions:

  • Age, race, and education are key factors influencing cognitive function.
  • Mydriatic drops did not significantly alter overall cognitive test scores.
  • Dilation prolonged MoCA test completion time in glaucoma patients, highlighting the need for extended patient-physician communication for this population.