Osteoporosis in chronic obstructive pulmonary disease
Elisabeth A P M Romme1, Frank W J M Smeenk, Erica P A Rutten
1Catharina Hospital, Department of Respiratory Medicine, PO Box 1350, 5602 ZA Eindhoven, The Netherlands. lisette.romme@catharinaziekenhuis.nl
Expert Review of Respiratory Medicine
|August 20, 2013
Summary
Osteoporosis is common in Chronic Obstructive Pulmonary Disease (COPD) patients due to shared risk factors and COPD-specific issues. This review details osteoporosis in COPD, covering its prevalence, causes, diagnosis, and management.
Area of Science:
- Pulmonary Medicine
- Bone Metabolism
- Geriatrics
Background:
- Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous condition with extrapulmonary manifestations, including osteoporosis.
- Osteoporosis, characterized by low bone mass and deterioration, increases fracture risk, particularly impacting morbidity and mortality in COPD patients.
Purpose of the Study:
- To provide a comprehensive review of osteoporosis in COPD patients.
- To summarize current knowledge on prevalence, pathophysiology, diagnosis, risk factors, and treatment.
- To explore potential mechanisms linking COPD and osteoporosis.
Main Methods:
- Literature review of current state-of-the-art research.
- Synthesis of information on epidemiological, etiological, diagnostic, and therapeutic aspects.
- Discussion of underlying pathogenetic links.
Main Results:
- Osteoporosis is highly prevalent in COPD patients.
- Common risk factors (age, smoking) and COPD-specific factors (inflammation, vitamin D deficiency, corticosteroid use) contribute to osteoporosis.
- Fractures in COPD patients exacerbate poor outcomes.
Conclusions:
- Osteoporosis is a significant comorbidity in COPD patients.
- Understanding the interplay between COPD and osteoporosis is crucial for patient management.
- Further research into shared mechanisms may reveal novel therapeutic targets.
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