Related Experiment Video
Updated: May 8, 2026
08:05
Assaying Protein Kinase Activity with Radiolabeled ATP
Published on: May 26, 2017
Bumping up kinase activity with an ATP-derived neo-substrate
Ralph E Kleiner1, Tarun M Kapoor
1Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY 10065, USA. rkleiner@rockefeller.edu
Cell
|August 20, 2013
Summary
Researchers developed a new method to activate the Parkinson
Area of Science:
- Biochemistry
- Neuroscience
- Pharmacology
Background:
- Reduced kinase activity is linked to diseases like Parkinson's.
- Developing treatments that enhance kinase function is crucial.
Purpose of the Study:
- To explore novel pharmacologic agents for treating kinase-deficiency disorders.
- To investigate an innovative approach for activating the Parkinson's-associated kinase PINK1.
Main Methods:
- Utilized an ATP-derived neo-substrate to activate PINK1.
- Employed cellular models to test the activation method.
Main Results:
- Successfully activated the PINK1 kinase in cells.
- Demonstrated the potential of the neo-substrate approach.
Conclusions:
- This strategy offers a new therapeutic avenue for Parkinson's disease.
- Pharmacologic activation of PINK1 is feasible and promising.
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