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Fabrication and characterisation of high performance polypyrrole modified microarray sensor for ascorbic acid

J Samseya1, R Srinivasan, Yu-Tsern Chang

  • 1Alagappa University, Karaikudi, Tamil Nadu, India.

Analytica Chimica Acta
|August 20, 2013
PubMed
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A novel polypyrrole-modified gold microelectrode array (Ppy/Au/MEA) offers a highly sensitive sensor for ascorbic acid (AA) detection. This advanced sensor achieves a low detection limit and enhanced sensitivity for AA determination in real samples.

Area of Science:

  • Electrochemistry
  • Materials Science
  • Biosensors

Background:

  • Gold microelectrode arrays (Au/MEA) are widely used in electrochemical sensing.
  • Polypyrrole (Ppy) is a conductive polymer with potential for biosensing applications.
  • Developing sensitive and selective sensors for ascorbic acid (AA) is crucial for various applications.

Purpose of the Study:

  • To fabricate and characterize a polypyrrole-modified gold microelectrode array (Ppy/Au/MEA) sensor.
  • To evaluate the electrocatalytic performance of the Ppy/Au/MEA sensor for ascorbic acid detection.
  • To compare the performance of Ppy/Au/MEA with a polypyrrole-modified gold macroelectrode (Ppy/Au/MA) sensor.

Main Methods:

  • Fabrication of Au/MEA using photolithography.
Keywords:
Ascorbic acidCyclic voltammetryGold micro array electrodePolypyrroleSquare wave voltammetry

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  • Modification of Au/MEA with Ppy via cyclic voltammetry.
  • Optimization of Ppy deposition parameters (potential range, cycles).
  • Characterization using Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM).
  • Electrochemical measurements using square wave voltammetry (SWV).

    • Main Results:

    • Optimized Ppy coating (3 cycles) resulted in a porous film (1.5 μm thickness) with high catalytic current for AA.
    • Ppy/Au/MEA sensor exhibited a low limit of detection (LOD) of 10 nm for AA at physiological conditions.
    • Enhanced sensitivity (2.5 mA cm(-2) mM(-1)) and a wide linear detection range (10 nm to 2.8 mM) were achieved.
    • Ppy/Au/MA sensor showed lower sensitivity (0.27 mA cm(-2) mM(-1)), higher LOD (5 μM), and a narrower linear range (10 μM to 2.2 mM).

    Conclusions:

    • The Ppy/Au/MEA sensor demonstrates superior performance for ascorbic acid detection compared to Ppy/Au/MA and previous sensor designs.
    • The porous Ppy coating contributes to the enhanced electrocatalytic activity and sensitivity.
    • Ppy/Au/MEA is a promising candidate for highly sensitive and reliable determination of AA in real samples.