Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma metabolites link healthy lifestyle to the risk of epilepsy in the UK Biobank.

Scientific reports·2026
Same author

Long non-coding RNA triplex-dependent regulation of melanoma gene networks.

NAR genomics and bioinformatics·2026
Same author

Circadian rhythm: The hidden "puppet master" behind musculoskeletal disorders.

Journal of orthopaedic translation·2026
Same author

Oxygen-generating Microparticles Enhance Viability and Functionality of Human Pluripotent Stem Cell-derived Cardiomyocytes for Myocardial Infarction Therapy.

Stem cell reviews and reports·2026
Same author

An embodied cognition based model of medical experts' tacit knowledge: structure, hierarchies, and transformation.

Frontiers in digital health·2026
Same author

GEX3 interacts with GEX2 to function in gamete attachment and plasma membrane fusion in Arabidopsis.

Plant communications·2026
Same journal

Clinical Outcome of Replanted Avulsed Anterior Teeth: A Retrospective Cohort Study.

Journal of endodontics·2026
Same journal

Mahidol study 3: Post-operative Effect and Adverse Events of Regenerative Endodontic Procedures in Immature Permanent Teeth.

Journal of endodontics·2026
Same journal

Non-Surgical Management of Horizontal Root Fracture with Necrotic Apical Segment and Coronal Cervical Abfraction Using Mineral Trioxide Aggregate: Case Report.

Journal of endodontics·2026
Same journal

Identification of pain-related biomarkers and the associated potential molecular regulation mechanism in pulpitis by bioinformatics method.

Journal of endodontics·2026
Same journal

AI Prognostic Models in Endodontics: Scoping Review and Clinical Gap Analysis for Retreatment vs Microsurgery Decision Support.

Journal of endodontics·2026
Same journal

AI-based 3D measurement of root canal curvature from CBCT: Validation of an automated Schneider angle analysis.

Journal of endodontics·2026
See all related articles

Related Experiment Video

Updated: May 8, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Potential correlation between statins and pulp chamber calcification.

Mary T Pettiette1, Sheng Zhong, Antonio J Moretti

  • 1Department of Endodontics, University of North Carolina School of Dentistry, Chapel Hill, North Carolina 27599-7450, USA. mary_pettiette@dentistry.unc.edu

Journal of Endodontics
|August 20, 2013
PubMed
Summary
This summary is machine-generated.

Systemic statin use in older adults was linked to increased dental pulp calcification, specifically a reduction in pulp chamber height. This suggests statins may contribute to pulp chamber calcification by enhancing odontoblastic activity.

Keywords:
Calcificationsodontoblastpulproot canalstatins

More Related Videos

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

Related Experiment Videos

Last Updated: May 8, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

Area of Science:

  • Dentistry
  • Pharmacology
  • Biomedical Science

Background:

  • 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) are primary treatments for dyslipidemia.
  • Statins have demonstrated the ability to induce odontoblastic differentiation in dental pulp stem cells.
  • Previous research indicates statins promote human dental pulp cell differentiation by increasing mineralization and odontogenic markers.

Purpose of the Study:

  • To investigate the hypothesis that systemic statin administration leads to increased dental pulp calcification.
  • To evaluate the effect of statins on pulp chamber dimensions in elderly patients.

Main Methods:

  • A retrospective case-control study involving 90 subjects aged 60 years and older.
  • Subjects were divided into a statin (test) group (n=45) and a non-statin (control) group (n=45).
  • Digital bitewing radiographs of mandibular molars were analyzed for pulp chamber height and mesiodistal dimensions using standardized measurements; statistical analysis included chi-square and multiple linear regression.

Main Results:

  • A significant reduction in the pulp chamber height ratio was observed in the statin group compared to the control group (P < .0001).
  • Three molars in the statin group showed nearly complete pulp chamber obliteration.
  • No significant difference in mesiodistal pulp chamber width was found between the groups (P = .3730).

Conclusions:

  • Systemic statin use was associated with increased pulp chamber calcification and a loss of vertical height in mandibular molars.
  • These findings suggest that statins may contribute to pulp chamber calcification, potentially through enhanced odontoblastic activity.