Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surgical management of type IV thoracoabdominal aortic aneurysm in a 4-year-old child: A case report and review of the literature.

Journal of vascular surgery cases and innovative techniquesĀ·2026
Same author

Bone Marrow Mesenchymal Stromal Cell Osteogenesis is driven by Paracrine signals from Regulatory T Cell.

Stem cell reviews and reportsĀ·2025
Same author

Fenestrated Endovascular Aortic Repair and Open Surgical Repair in Patients with Type Ia Endoleak after Endovascular Aneurysm Repair: a French Multicentre Cohort Study with Propensity Score Matching.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular SurgeryĀ·2025
Same author

Early and Long-Term Outcomes of Cryopreserved Arterial Allograft Reconstruction in Concomitant Aortic and Spinal Infections Managed with a Multidisciplinary Approach.

Annals of vascular surgeryĀ·2025
Same author

Dense Calcification of the Common Femoral Artery Is Protective Against In-Stent Restenosis.

Journal of clinical medicineĀ·2025
Same author

Early and Mid-term Results From a Tertiary Care Center for Total Aortic Arch Replacement Using the Thoraflex Hybrid Graft.

Vascular and endovascular surgeryĀ·2025

Related Experiment Video

Updated: May 8, 2026

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
09:34

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

Pre-vascularization of bone tissue-engineered constructs.

Meadhbh Brennan, Jean-Michel Davaine, Pierre Layrolle

    Stem Cell Research & Therapy
    |August 20, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Researchers found that combining endothelial cells and mesenchymal stem cells in tissue engineering creates functional blood vessels. This approach is key for repairing bone defects and improving implant integration.

    More Related Videos

    The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering
    08:53

    The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

    Published on: November 2, 2016

    Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering
    07:09

    Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering

    Published on: April 30, 2017

    Related Experiment Videos

    Last Updated: May 8, 2026

    Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
    09:34

    Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

    Published on: September 7, 2017

    The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering
    08:53

    The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

    Published on: November 2, 2016

    Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering
    07:09

    Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering

    Published on: April 30, 2017

    Area of Science:

    • Biomedical Engineering
    • Regenerative Medicine
    • Tissue Engineering

    Background:

    • Vascularization is a major challenge in bone defect repair.
    • Tissue-engineered constructs are being explored to address this limitation.
    • Mesenchymal stem cells (MSCs) show potential in supporting vascularization.

    Purpose of the Study:

    • To evaluate the efficacy of co-immobilized endothelial cells and MSCs in creating vascularized tissue-engineered constructs.
    • To highlight the role of MSCs in supporting in vivo vascular network formation.
    • To discuss the implications for developing pre-vascularized bone defect repair strategies.

    Main Methods:

    • Co-immobilization of endothelial cells and MSCs within a tissue-engineered construct.
    • In vivo assessment of functional microvascular network formation.
    • Commentary on recent advancements in vascularization for bone repair.

    Main Results:

    • Successful achievement of functional microvascular networks in vivo through co-immobilization.
    • Demonstration of MSCs' supportive role for nascent blood vessels.
    • Evidence of enhanced integration potential for pre-vascularized implants.

    Conclusions:

    • Co-immobilization of endothelial cells and MSCs is a promising strategy for generating vascularized tissue.
    • MSCs are crucial supporting cells for vascular development in engineered tissues.
    • Developing pre-vascularized implants using clinical cell sources could significantly advance bone defect repair.