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Spring-like fibers for cardiac tissue engineering.

Sharon Fleischer1, Ron Feiner, Assaf Shapira

  • 1The Laboratory for Tissue Engineering and Regenerative Medicine, Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Science, Tel Aviv University, Tel Aviv 69978, Israel.

Biomaterials
|August 20, 2013
PubMed
Summary

Engineered cardiac tissue using novel 3D spring-like fiber scaffolds demonstrated enhanced contraction force and function. This biomimetic scaffold advances cardiac tissue engineering for potential therapeutic applications.

Keywords:
Cardiac tissue engineeringCoiled fibersElectrospinningMyocardial infarctionPerimysial fibers

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Last Updated: May 8, 2026

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Cardiovascular Research

Background:

  • Mimicking the native cardiac microenvironment is crucial for functional cardiac tissue engineering.
  • Existing scaffolds often fail to replicate the dynamic mechanical properties of myocardial fibers.

Purpose of the Study:

  • To develop and evaluate a novel 3-dimensional (3D) spring-like fiber scaffold for cardiac tissue engineering.
  • To investigate if this scaffold can enhance the functional properties of engineered cardiac tissue.

Main Methods:

  • Fabrication of 3D spring-like fiber scaffolds mimicking cardiac perimysial fibers.
  • Mechanical testing of single fibers and 3D scaffolds (elasticity, extensibility).
  • Cultivation of cardiac cells on scaffolds and assessment of tissue function (contraction force, beating rate, excitation threshold).

Main Results:

  • Spring-like fibers and scaffolds exhibited superior elasticity and extensibility compared to straight controls.
  • Cardiac cells on spring-like fibers showed induced stretching in the direction of contraction.
  • Engineered cardiac tissue in 3D spring-like scaffolds demonstrated significantly stronger contraction force, higher beating rate, and lower excitation threshold.

Conclusions:

  • 3D spring-like fiber scaffolds effectively mimic cardiac microenvironment mechanics.
  • These scaffolds promote the development of functional cardiac tissue with enhanced contractile properties.
  • This biomimetic approach holds promise for improving cardiac function post-infarction.