[Large cell calcifying Sertoli cell tumour: A case report].

Area of Science:

• Oncology
• Uropathology
• Endocrinology

Background:

• Sertoli cell tumors (SCTs) are rare testicular neoplasms, typically benign, originating from the supportive cells of the seminiferous tubules.
• Large cell calcifying Sertoli cell tumors (LCCSCTs) represent a distinct subtype, characterized by specific histological features and potential associations with genetic syndromes.
• Testicular masses in young men warrant thorough investigation to differentiate between neoplastic and non-neoplastic conditions.

Observation:

• A 19-year-old male presented with a painless, palpable right testicular mass.
• Physical examination showed no signs of gynecomastia or abnormal skin pigmentation.
• Initial laboratory tests, including serum alpha-fetoprotein, beta-human chorionic gonadotropin (β-HCG), and testosterone, were within normal limits.

Findings:

• Sonography revealed a diffusely hyperechoic intratesticular lesion with acoustic shadowing, suggesting a calcified or dense mass.
• Histopathological examination following right orchiectomy confirmed the diagnosis of a benign large cell calcifying Sertoli cell tumor.
• The tumor was characterized by large Sertoli cells with prominent calcifications.

Implications:

• This case highlights the importance of considering rare testicular tumors even in the absence of typical tumor markers or clinical signs.
• Accurate diagnosis of LCCSCTs is crucial, as they are generally benign but may be associated with genetic abnormalities like Carney complex or Peutz-Jeghers syndrome.
• Further research into the genetic underpinnings and long-term management of LCCSCTs is warranted to optimize patient outcomes.