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Published on: November 19, 2014
Reduced delta power and synchrony and increased gamma power during the P3 time window in schizophrenia
Franc C L Donkers1, Zoë A Englander, Paul H E Tiesinga
1University of North Carolina at Chapel Hill, Department of Psychiatry, Chapel Hill, NC, USA; Tilburg University, Department of Psychology, Tilburg, the Netherlands.
Background:
Event-related potential studies in schizophrenia have demonstrated amplitude reduction of the P3 in oddball tasks. The P3 has been linked to attention and memory brain functions.
Methods:
In 24 schizophrenia patients and 28 control subjects, wavelet transform was used to reveal event-related modulations of the EEG signal during target trials in delta, theta, alpha, beta, and gamma frequency bands.
Results:
Patients showed reductions in P3 amplitude accompanied by reduced low frequency delta-theta and increased beta-gamma band EEG activity.
Conclusions:
These results indicate abnormalities in the synchronization and/or efficiency of neural processes involved in memory and attention networks in schizophrenia.
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