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Updated: May 8, 2026

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Implication of the TRPM4 nonselective cation channel in mammalian sinus rhythm

Thomas Hof1, Christophe Simard, René Rouet

  • 1Normandie Université, EA 4650, Groupe Signalisation, Electrophysiologie et Imagerie des Lésions d'Ischémie-Reperfusion Myocardique, UCBN, Caen, France.

Heart Rhythm
|August 20, 2013
PubMed
Abstract

Keywords:
APAPAAPD(50)APD(70)APD(90)BradycardiaCa(2+)-activated nonselective cation channelCa(2+)-activated nonselective cation channelsDDEC(50)Heart rateI(Ca,L)I(Ca,T)I(f)L-type Ca(2+) currentNSC(Ca)RMPSANSinus nodeT-type Ca(2+) currentTRPMTransient receptor potential melastatin 4V(max)WTaction potentialaction potential amplitudeaction potential duration at 50% repolarizationaction potential duration at 70% of repolarizationaction potential duration at 90% of repolarizationconcentration for half maximal effectdiastolic depolarizationfunny currentmaximum upstroke velocityresting membrane potentialsinoatrial nodetransient receptor potential melastatinwild type

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