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Updated: May 8, 2026
Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis
Published on: June 20, 2012
Prospective slice-by-slice motion correction reduces false positive activations in fMRI with task-correlated motion
J Schulz1, T Siegert, P-L Bazin
1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Objective:
We aimed to test the hypothesis that slice-by-slice prospective motion correction at 7T using an optical tracking system reduces the rate of false positive activations in an fMRI group study with a paradigm that involves task-correlated motion.
Materials And Methods:
Brain activation during right leg movement was measured using a block design on 15 volunteers, with and without prospective motion correction. Clearly erroneous activations were compared between both cases, at the individual level. Additionally, conventional group analysis was performed.
Results:
The number of falsely activated voxels with T-values higher than 5 was reduced by 48% using prospective motion correction alone, without additional retrospective realignment. In the group analysis, the statistical power was increased - the peak T-value was 26% greater, and the number of voxels in the cluster representing the right leg was increased by a factor of 9.3.
Conclusion:
Slice-by-slice prospective motion correction in fMRI studies with task-correlated motion can substantially reduce false positive activations and increase statistical power.
