Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Asymmetric Lipid Bilayer

Asymmetric Lipid Bilayer

Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...

Membrane Lipids

Membrane Lipids

Lipids are an essential component of all biological membranes. The average lipid content in mammalian membranes is 50%, though it can be as low as 20% in the inner mitochondrial membrane or as high as 80% in the myelin sheath present around the nerve cells.
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...

Biosynthesis of Lipids

Biosynthesis of Lipids

Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis pathway, which...

Phosphoinositides and PIPs

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...

Membrane Domains

Membrane Domains

The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the anterior...

Membrane Fluidity

Membrane Fluidity

Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

dbPTH: A Comprehensive Database for Protein Targets of Herbal Ingredients.

Genomics, proteomics & bioinformatics·2026

Same author

Impact of inferior pulmonary ligament dissection versus preservation during thoracoscopic upper lobectomy: a retrospective comparative analysis.

Frontiers in surgery·2026

Same author

Traumatic cardiac rupture with cerebral herniation: A case report.

Medicine·2026

Same author

A deep learning and large language hybrid workflow for omics interpretation.

Nature biomedical engineering·2026

Same author

wViP: an online server of word cloud visualization of biological profiles.

Science bulletin·2025

Same author

Synergistic Enhancement of Anti-aging Effects on Human Umbilical Vein Endothelial Cells Treated With the Combination of Ferulic Acid and Rapamycin.

Current aging science·2025

Search research articles

Related Experiment Video

Updated: May 8, 2026

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans

Published on: December 9, 2022

Sphingolipids and lifespan regulation.

Xinhe Huang¹, Bradley R Withers¹, Robert C Dickson¹

¹Department of Molecular and Cellular Biochemistry and the Lucille Markey Cancer Center, University of Kentucky College of Medicine, 741 S. Limestone, Lexington, KY 40536, USA.

Biochimica Et Biophysica Acta

|August 20, 2013

Summary

Modulating sphingolipids can prevent or delay age-associated diseases, improving healthspan in elderly individuals. Lowering sphingolipid levels, particularly via serine palmitoyltransferase inhibition, shows promise for promoting longevity.

Keywords:

Aging Autophagy Ceramide Myriocin Sphingosing-1-phosphate

More Related Videos

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

Related Experiment Videos

Last Updated: May 8, 2026

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans

Published on: December 9, 2022

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

Area of Science:

Gerontology
Biochemistry
Cellular Biology

Background:

Aging increases prevalence of diseases like cancer, diabetes, and neurodegeneration.
Increased human lifespan exacerbates the healthcare burden from age-related diseases.
Sphingolipids play a crucial role in cellular signaling pathways implicated in aging.

Purpose of the Study:

To explore strategies for modulating sphingolipids to prevent or delay age-associated diseases.
To improve healthspan and potentially lifespan in elderly populations.
To leverage advances in understanding conserved eukaryotic signaling pathways.

Main Methods:

Focus on modulating sphingolipid concentrations and their associated signaling pathways.
Investigating the role of the Target of Rapamycin Complex 1 (TORC1) pathway.
Examining the inhibition of serine palmitoyltransferase, the rate-limiting enzyme in sphingolipid biosynthesis.

Main Results:

Lowering sphingolipid levels shows promise in model organisms for reducing signs of aging.
Modulating sphingolipids may decrease oxidative stress, inflammation, and growth factor signaling.
Inhibiting serine palmitoyltransferase is a particularly promising strategy for longevity.

Conclusions:

Sphingolipid modulation offers a viable approach to combat age-associated diseases.
Interventions targeting sphingolipid metabolism can enhance healthspan in the elderly.
Further research into molecular mechanisms will refine strategies for promoting longevity through sphingolipid manipulation.