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Updated: May 8, 2026

Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy
Published on: November 30, 2018
Fructose restrains fibrillogenesis in human serum albumin
Nitin K Pandey1, Sudeshna Ghosh, Swagata Dasgupta
1Department of Chemistry, Indian Institute of Technology, Kharagpur, Kharagpur 721302, India.
Abstract:
The endogenous deposition of protein aggregates with fibrillar morphology is known to govern the genesis of several neurodisorders. The investigation of naturally occurring small molecules which can restrict the fibrillation process can help in the design of rational therapeutics for neurodegenerative diseases. We report the inhibition of HSA fibrillation in the presence of naturally occurring sugars such as glucose, fructose, ribose and sucrose with fructose being the most potent. We have characterized the inhibitory potency of the sugars, using different spectroscopic and microscopic techniques.
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