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Updated: May 8, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Published on: July 6, 2013
Immunization to prevent congenital cytomegalovirus infection
1Department of Microbiology, Medical College of Virginia Campus/Virginia Commonwealth University, PO Box 163, Richmond, VA 23298, USA. sadler@vcu.edu
Introduction:
A primary maternal cytomegalovirus (CMV) during pregnancy causes newborn disease that includes hearing deficit and/or mental retardation.
Sources Of Data:
Relevant published literature.
Areas Of Agreement:
There are no biologic obstacles to immunization against fetal/placental infection with CMV.
Areas Of Uncertainty:
CMV vaccine trials may be difficult due to a lack of public awareness of CMV. Vaccine trials that use fetal infection as an endpoint will be prolonged, since vaccination will need to occur preconception.
Areas Timely For Developing Research:
Vaccines in preclinical development include antigens of the CMV gB glycoprotein and the gH/gL UL128, 130 and 131 pentameric complex. These antigens induce antibodies that block viral entry into fibroblasts and endothelial/epithelial cells. Vaccines immunogenic in animals include an inactivated virus with a wild-type UL131 gene, a DNA vaccine using a wild-type UL130 gene and peptide vaccines using peptides from UL130 and 131.
Conclusions:
In spite of these potential obstacles, successful evaluation of CMV vaccines is possible.
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