Related Experiment Video

Updated: May 8, 2026

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS) for Quantification of Iron Redox Species (Fe(II), Fe(III))
04:48

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS) for Quantification of Iron Redox Species (Fe(II), Fe(III))

Published on: May 4, 2020

Blood manganese concentration is elevated in infants with iron deficiency

Sangkyu Park1, Chang-Sun Sim, Heun Lee

  • 1Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.

Biological Trace Element Research
|August 20, 2013
PubMed

Insights

Iron deficiency in infants is linked to higher blood manganese (Mn) levels. Supplementing with iron normalized Mn levels, suggesting iron deficiency increases Mn absorption.

Area of Science:

  • Pediatric Nutrition
  • Trace Element Metabolism
  • Hematology

Background:

  • Iron deficiency is common in infants and can affect various physiological processes.
  • Manganese (Mn) is an essential trace element, but its levels in relation to iron status are not well understood in infants.
  • Understanding nutrient interactions is crucial for optimal infant health and development.

Purpose of the Study:

  • To investigate the relationship between iron deficiency and blood manganese concentration in infants.
  • To determine if iron supplementation affects blood manganese levels in iron-deficient infants.

Main Methods:

  • A comparative study involving 31 iron-deficient infants and 36 healthy controls (aged 6-24 months).
  • Measurements included blood manganese, complete blood counts, serum ferritin, and iron/transferrin iron-binding capacity (Fe/TIBC).
  • Iron-deficient infants received iron supplementation, with follow-up measurements for a subset (n=19).

Main Results:

  • Infants with iron deficiency exhibited significantly higher blood manganese concentrations compared to controls.
  • Following iron therapy, blood manganese levels in previously deficient infants decreased significantly.
  • Iron supplementation led to significant increases in hemoglobin and ferritin levels in the treated infants.

Conclusions:

  • Iron deficiency is associated with elevated blood manganese levels in infants.
  • Iron therapy effectively reduces blood manganese concentrations in iron-deficient infants.
  • The findings suggest that iron deficiency may enhance manganese absorption in infants.

More Related Videos

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

Related Concept Videos

Microbes and Other Elemental Cycles01:24

Microbes and Other Elemental Cycles

Microbial activity plays a pivotal role in the biogeochemical cycling of iron and manganese, especially at the redox gradients characteristic of stratified aquatic environments. These cycles are driven by microbial transformations between oxidized and reduced forms of the metals, allowing organisms to exploit them for metabolic energy and structural purposes.Iron Cycling Across Redox GradientsIn neutral, oxygen-rich surface waters, iron is predominantly found in its oxidized, insoluble ferric...
The Periodic Table and Organismal Elements00:57

The Periodic Table and Organismal Elements

OverviewElements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally-occurring, and fewer still are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.The Periodic Table Provides Information...
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Minerals01:26

Minerals

Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...