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Relationship between Rosai-Dorfman disease and IgG4-related disease: study of 32 cases
Liping Liu1, Anamarija M Perry, Wenfeng Cao
1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
Objectives:
To assess the association between Rosai-Dorfman disease (RDD) and IgG4-related disease (IgG4-RD).
Methods:
We studied the number of IgG4-positive plasma cells and the IgG4/IgG ratio in 32 biopsy specimens (13 nodal, 19 extranodal) from 29 patients with RDD and compared the findings with those in IgG4-RD of the pancreas and reactive lymph nodes. We also assessed the number of FOXP3-positive regulatory T cells (Tregs) since they were reported to be increased in IgG4-RD.
Results:
We found that RDD cases had much lower numbers of IgG4-positive plasma cells and lower IgG4/IgG ratios compared with IgG4-RD but were similar to reactive lymph nodes. Furthermore, RDD had lower numbers of FOXP3-positive Tregs than did IgG4-RD. There were no significant differences in the number of IgG4-positive plasma cells and the IgG4/IgG ratio between the nodal and extranodal RDD cases.
Conclusions:
Our study suggests that RDD does not belong in the spectrum of IgG4-RD.
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