Pediatric allergic rhinitis and asthma: can the march be halted?

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Olympia A Tsilochristou1, Nikolaos Douladiris, Michael Makris

  • 1Allergy Unit "D. Kalogeromitros," Medical School, "Attikon" University Hospital, 1, Rimini str, 124 62, Chaidari, Athens, Greece, ol.tsilochristou@gmail.com.

Paediatric Drugs
|August 20, 2013
PubMed

Insights

Early childhood interventions for allergic rhinitis (AR) and asthma show promise for altering respiratory allergy progression. Specific allergen immunotherapy offers a potential disease-modifying effect for united airways disease.

Area of Science:

  • Allergy and Immunology
  • Pediatric Respiratory Medicine
  • Clinical Medicine

Background:

  • Allergic rhinitis (AR) and asthma are linked as 'united airways disease' or 'respiratory allergy'.
  • Progression from AR to asthma is common, part of the 'atopic march'.
  • Pediatric immune systems are adaptable, suggesting early intervention potential.

Purpose of the Study:

  • To explore the potential of early childhood interventions in modifying the natural history of respiratory allergy.
  • To evaluate the disease-modifying effects of allergen immunotherapy and emerging treatments for united airways disease.

Main Methods:

  • Review of epidemiologic and pathophysiologic links between AR and asthma.
  • Analysis of current treatment efficacy in symptom alleviation versus disease progression.
  • Assessment of evidence for specific allergen immunotherapy and novel preventive strategies.

Main Results:

  • Current AR treatments effectively manage symptoms but struggle to halt disease progression.
  • Specific allergen immunotherapy shows promising, though not definitive, disease-modifying effects.
  • Emerging and targeted interventions present future preventive possibilities for respiratory allergy.

Conclusions:

  • Early interventions in childhood may impact the natural course of respiratory allergy.
  • Allergen immunotherapy is a key area for disease modification in united airways disease.
  • Further research into novel and targeted therapies is crucial for prevention and management.

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