Related Experiment Video
Updated: May 8, 2026
06:08
Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
Published on: September 22, 2023
Pediatric allergic rhinitis and asthma: can the march be halted?
Olympia A Tsilochristou1, Nikolaos Douladiris, Michael Makris
1Allergy Unit "D. Kalogeromitros," Medical School, "Attikon" University Hospital, 1, Rimini str, 124 62, Chaidari, Athens, Greece, ol.tsilochristou@gmail.com.
Paediatric Drugs
|August 20, 2013
Summary
Early childhood interventions for allergic rhinitis (AR) and asthma show promise for altering respiratory allergy progression. Specific allergen immunotherapy offers a potential disease-modifying effect for united airways disease.
Area of Science:
- Allergy and Immunology
- Pediatric Respiratory Medicine
- Clinical Medicine
Background:
- Allergic rhinitis (AR) and asthma are linked as 'united airways disease' or 'respiratory allergy'.
- Progression from AR to asthma is common, part of the 'atopic march'.
- Pediatric immune systems are adaptable, suggesting early intervention potential.
Purpose of the Study:
- To explore the potential of early childhood interventions in modifying the natural history of respiratory allergy.
- To evaluate the disease-modifying effects of allergen immunotherapy and emerging treatments for united airways disease.
Main Methods:
- Review of epidemiologic and pathophysiologic links between AR and asthma.
- Analysis of current treatment efficacy in symptom alleviation versus disease progression.
- Assessment of evidence for specific allergen immunotherapy and novel preventive strategies.
Main Results:
- Current AR treatments effectively manage symptoms but struggle to halt disease progression.
- Specific allergen immunotherapy shows promising, though not definitive, disease-modifying effects.
- Emerging and targeted interventions present future preventive possibilities for respiratory allergy.
Conclusions:
- Early interventions in childhood may impact the natural course of respiratory allergy.
- Allergen immunotherapy is a key area for disease modification in united airways disease.
- Further research into novel and targeted therapies is crucial for prevention and management.
Related Concept Videos
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
01:19Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:17Drugs Used in Lower Respiratory Disorders: Overview
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
01:30Asthma-IV: Diagnostic and Management
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes: