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Related Concept Videos

Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
Magnetic Field Of A Current Loop01:16

Magnetic Field Of A Current Loop

Consider a circular loop with a radius a, that carries a current I. The magnetic field due to the current at an arbitrary point P along the axis of the loop can be calculated using the Biot-Savart law.

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Related Experiment Video

Updated: May 8, 2026

MRM Microcoil Performance Calibration and Usage Demonstrated on Medicago truncatula Roots at 22 T
10:22

MRM Microcoil Performance Calibration and Usage Demonstrated on Medicago truncatula Roots at 22 T

Published on: January 16, 2021

A microfluidically cryocooled spiral microcoil with inductive coupling for MR microscopy.

Chiwan Koo, Richard F Godley, Mary P McDougall

    IEEE Transactions on Bio-Medical Engineering
    |August 20, 2013
    PubMed
    Summary
    This summary is machine-generated.

    We developed a microfluidic cryocooling system for magnetic resonance (MR) microscopy microcoils. This method enhances signal-to-noise ratio (SNR) by cooling both the coil and capacitor, improving MR imaging of small samples.

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    Last Updated: May 8, 2026

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    11:27

    Magnetically-Assisted Remote Controlled Microcatheter Tip Deflection under Magnetic Resonance Imaging

    Published on: April 4, 2013

    Area of Science:

    • Magnetic Resonance Imaging (MRI)
    • Microscopy
    • Cryogenics

    Background:

    • Microcoils are crucial for high signal-to-noise ratio (SNR) in magnetic resonance (MR) microscopy.
    • Copper losses in microcoils limit SNR, often addressed by cryocooling.
    • Cryocooling matching networks improves SNR but presents engineering challenges.

    Purpose of the Study:

    • To develop a microfluidic cryocooling system for integrated microcoil and capacitor arrays.
    • To enhance SNR in MR microscopy by localized cooling.
    • To maintain optimal sample-to-coil distance for sensitive imaging.

    Main Methods:

    • Fabrication of a spiral microcoil with integrated parallel plate capacitors.
    • Implementation of a microfluidic channel for localized cryocooling of the coil and capacitor.
    • Use of inductive coupling to connect the microcoil to the tuning network, minimizing cooling loss.
    • Q-factor measurements for cooled and uncooled configurations.

    Main Results:

    • Achieved localized cryocooling of both the microcoil and on-chip capacitor.
    • Demonstrated a 2.6x improvement in Q-factor compared to a reference coil.
    • Validated theoretical predictions for SNR enhancement through cryocooling.

    Conclusions:

    • Microfluidic cryocooling offers an effective method to boost SNR in MR microscopy.
    • Integrated coil and capacitor cooling with inductive coupling minimizes losses and maximizes performance.
    • This approach advances the capability for high-resolution imaging of minute biological and material samples.