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Single dose prophylaxis in colorectal surgery.

I P Bissett1, W H Isbister

  • 1Department of Surgery, Wellington Clinical School of Medicine.

The New Zealand Medical Journal
|September 12, 1990
PubMed
Summary
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Single-dose moxalactam disodium (Latamoxef) prophylaxis in colorectal surgery showed a 13% wound infection rate. This approach is cost-effective with few side effects, justifying its use.

Area of Science:

  • Surgical Infection Prevention
  • Pharmacology
  • Clinical Microbiology

Background:

  • Wound infections are a significant complication in open colorectal surgery.
  • Optimizing antibiotic prophylaxis is crucial for reducing surgical site infections.
  • Previous studies utilized prolonged antibiotic regimens.

Purpose of the Study:

  • To evaluate moxalactam disodium (Latamoxef) as a single-dose prophylactic antibiotic.
  • To assess the efficacy and safety of moxalactam disodium in open colorectal surgery.
  • To determine the wound infection rate associated with single-dose prophylaxis.

Main Methods:

  • A prospective study involving 105 consecutive patients undergoing open colorectal surgery.
  • Moxalactam disodium (1g) administered as a single dose at anesthesia induction.

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  • Exclusion criteria included non-administration or alternative antibiotic use.
  • Wound infection rates were monitored for early and late infections.

    • Main Results:

    • Eleven early and one late wound infection were observed, resulting in a 13% overall infection rate (95% CI 7-19).
    • The observed infection rate was higher than a previous study using prolonged prophylaxis (9.8%), but the difference was not statistically significant due to unmatched patient groups.
    • Moxalactam disodium was associated with a low incidence of side effects.

    Conclusions:

    • Single-dose moxalactam disodium (1g) is a cost-effective prophylactic antibiotic for open colorectal surgery.
    • The low side effect profile supports its continued use.
    • Further investigation may be warranted, considering the observed infection rate compared to prolonged prophylaxis.