Related Experiment Video
Updated: May 8, 2026
Insights into the Interactions of Amino Acids and Peptides with Inorganic Materials Using Single-Molecule Force Spectroscopy
Published on: March 6, 2017
Insights into the molecular architecture of a peptide nanotube using FTIR and solid-state NMR spectroscopic
David A Middleton1, Jillian Madine, Valeria Castelletto
1Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool L69 7ZB (UK). middleda@liverpool.ac.uk.
Abstract:
Queuing up: Molecular orientation within macroscopically aligned nanotubes of the peptide AAAAAAK can be studied by solid-state NMR and IR spectroscopy. Line shape analysis of the NMR spectra indicates that the peptide N-H bonds are tilted 65-70° relative to the nanotube long axis. Re-evaluation of earlier X-ray fiber diffraction data suggests that the peptide molecules are hydrogen-bonded in a helical arrangement along the nanotube axis.
