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Updated: May 1, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Total synthesis and structural revision of laurefurenynes A and B
Michael T Holmes1, Robert Britton
1Department of Chemistry, Simon Fraser University, Burnaby, V5A 1S6, BC (Canada), Fax: (+1) 1-778-782-3765.
Abstract:
Structural reassignment: A total synthesis of the proposed structure of (-)-laurefurenyne A has been accomplished that relies on organocatalytic aldehyde α-chlorination and a flexible chlorohydrin-based strategy for stereocontrolled access to the bis-tetrahydrofuran core of the natural product. Analysis of incongruities between the (1) H NMR spectra of synthetic and natural material led to a configurational reassignment for the natural product, which was also confirmed by total synthesis.
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