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Related Experiment Video

Updated: May 8, 2026

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
09:40

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Published on: June 20, 2018

ACE2 alterations in kidney disease.

María José Soler1, Jan Wysocki, Daniel Batlle

  • 1Department of Nephrology, Hospital del Mar-Fundació IMIM, Barcelona, Spain.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|August 20, 2013
PubMed
Summary
This summary is machine-generated.

Angiotensin-converting enzyme 2 (ACE2) plays a key role in kidney health. This review examines how ACE2 expression and activity change in various kidney diseases, offering insights into disease mechanisms.

Keywords:
ACE2kidney diseaserenin–angiotensin system

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Published on: May 2, 2025

Area of Science:

  • Nephrology
  • Renal Physiology
  • Enzymology

Background:

  • Angiotensin-converting enzyme 2 (ACE2) is a critical enzyme in the renin-angiotensin system, primarily degrading angiotensin II into angiotensin-(1-7).
  • ACE2 is abundantly expressed in the kidneys, particularly in tubular epithelial cells, with lower expression in glomerular cells and renal vasculature.
  • Altered ACE2 activity is implicated in diabetic kidney disease, hypertensive renal disease, and other kidney injury models.

Purpose of the Study:

  • To review recent findings on alterations in circulating and renal ACE2 in various kidney pathologies.
  • To discuss the potential significance of these ACE2 changes in the context of renal disease.
  • To highlight the dissociation between tubular and glomerular ACE2 expression observed in certain kidney conditions, such as diabetic kidney disease.

Main Methods:

  • Literature review of studies investigating ACE2 in renal pathologies.
  • Analysis of data on ACE2 expression and activity in different kidney disease models.
  • Synthesis of information regarding the localization and functional changes of ACE2 in the kidney.

Main Results:

  • ACE2 expression and activity are frequently altered in diverse renal pathologies and injury models.
  • A notable dissociation in ACE2 expression is observed between tubular and glomerular compartments, especially in diabetic kidney disease.
  • Changes in circulating ACE2 levels may correlate with renal conditions.

Conclusions:

  • Alterations in renal ACE2 are significant features of various kidney diseases.
  • Understanding ACE2 dysregulation provides insights into pathogenic mechanisms and potential therapeutic targets.
  • Further research is warranted to fully elucidate the role of ACE2 in kidney health and disease.