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Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...

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Related Experiment Videos

Hypersensitivity to suture anchors.

Masafumi Goto1, Masafumi Gotoh, Yasuhiro Mitsui

  • 1Department of Orthopedic Surgery, Kurume University Medical Center, 155 Kokubu-machi, Kurume, Fukuoka 839-0863, Japan.

Case Reports in Orthopedics
|August 20, 2013
PubMed
Summary
This summary is machine-generated.

Hypersensitivity to metal suture anchors is rare. A patient experienced allergic reactions despite negative patch tests; anchor removal resolved symptoms, suggesting it as a treatment option.

Related Experiment Videos

Area of Science:

  • Orthopedic Surgery
  • Dermatology
  • Allergy & Immunology

Background:

  • Suture anchors are commonly used in orthopedic procedures like rotator cuff repair.
  • Hypersensitivity reactions to metallic implants are uncommon but can cause significant morbidity.
  • This case highlights a potential diagnostic challenge in identifying implant-related allergies.

Purpose of the Study:

  • To report a rare case of suspected hypersensitivity to a metal suture anchor.
  • To discuss the diagnostic process and management of implant-related allergic reactions.
  • To emphasize the consideration of implant removal even with negative allergy testing.

Main Methods:

  • A 50-year-old female patient underwent rotator cuff repair using a metal suture anchor.
  • Post-operative erythema and itching developed, prompting investigation for hypersensitivity.
  • Dermatological patch testing was performed to assess for metallic allergies.

Main Results:

  • The patient presented with widespread erythema and itching three weeks post-surgery.
  • Standard infection workup was negative, raising suspicion of a metallic allergy.
  • Patch testing for titanium, aluminum, and vanadium yielded negative results.
  • Symptom resolution was immediate upon removal of the suture anchor.

Conclusions:

  • Metal suture anchor hypersensitivity, though rare, should be considered in persistent post-operative allergic symptoms.
  • Negative patch test results do not exclude implant-related hypersensitivity.
  • Suture anchor removal can be an effective treatment for suspected implant hypersensitivity.