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Related Experiment Video

Updated: May 8, 2026

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

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Published on: May 14, 2016

Targeting Cdc42 in cancer.

Luis E Arias-Romero¹, Jonathan Chernoff

¹Cancer Biology Program, Fox Chase Cancer Center , Philadelphia, PA , USA +1 215 728 5319 ; +1 215 728 3616 ; Jonathan.Chernoff@fccc.edu.

Expert Opinion on Therapeutic Targets

|August 21, 2013

Summary

This summary is machine-generated.

Cdc42, a Rho GTPase, is overexpressed in many cancers and linked to poor prognosis. Targeting Cdc42 or its effectors may offer new therapeutic strategies for cancers with activating Ras mutations.

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Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

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Published on: May 14, 2016

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors

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Published on: July 17, 2020

Area of Science:

Molecular Biology
Cellular Signaling
Oncology

Background:

Rho GTPases are key regulators of cellular processes, acting as molecular switches.
Cdc42, a Rho family member, is implicated in various human cancers.
Aberrant Cdc42 expression correlates with poor prognosis in some malignancies.

Purpose of the Study:

To describe key regulators and effectors of Cdc42.
To analyze molecular alterations in Cdc42 signaling.
To explore Cdc42's role in tumorigenesis and potential therapeutic targeting.

Main Methods:

Review of literature on Cdc42 regulators and effectors.
Analysis of molecular alterations in Cdc42 signaling pathways.
Examination of Cdc42's role in Ras-mediated tumorigenesis.

Main Results:

Cdc42 mutations are not reported in human cancer.
Aberrant Cdc42 expression is observed in diverse tumor types.
Cdc42 activation by oncogenic Ras is critical for tumorigenesis.

Conclusions:

Targeting Cdc42 or its downstream effectors presents a potential therapeutic strategy.
This approach is particularly relevant for tumors with activating Ras mutations.
Cdc42 represents a promising target for novel cancer therapies.